Gene Editing & Biotech (CRISPR)
Module 06 — Rewriting Life
Target Phenomenon
Can we cure genetic diseases? The ethics and science of CRISPR-Cas9.
NGSS Standards
- HS-LS1-1 — Construct an explanation based on evidence for how the structure of DNA determines the structure of proteins which carry out the essential functions of life through systems of specialized cells. (DNA → protein)
- HS-LS3-1 — Ask questions to clarify relationships about the role of DNA and chromosomes in coding the instructions for characteristic traits passed from parents to offspring. (Gene technology)
- HS-LS3-2 — Make and defend a claim based on evidence that inheritable genetic variations may result from new genetic combinations through meiosis, viable errors occurring during replication, and/or mutations caused by environmental factors. (Variation)
Lesson Breakdown
| Lesson | Title | Focus | NGSS Practice |
|---|---|---|---|
| L01 | The Molecular Scissors | How CRISPR-Cas9 works (mechanism) | Developing & Using Models |
| L02 | Broken Code | Genetic diseases as “typos” in DNA | Analyzing & Interpreting Data |
| L03 | Rewriting the Edit | Students simulate gene editing | Planning & Carrying Out Investigations |
| L04 | Designer Babies & Beyond | Applications and misuses | Engaging in Argument from Evidence |
| L05 | Where Do We Draw the Line? | Ethics debate and synthesis | Constructing Explanations |
Total: 5 lessons
Recommended Prior Module
M05 — Bad Blood (Genetics)
Notes
Retooled from legacy CRISPR unit. Students debate bioethics, model gene editing with simulations.